All SetaPDF APIs are written in pure PHP and does not need any other libraries installed except a PHP environment of a version later than 4.3 and an installed Zend Optimizer or installed Ioncube loader.
The SetaPDF-Signer API currently makes use of the OpenSSL Library. It is possible to use the OpenSSL Library through the command line or through the php build in OpenSSL functions. At least it requires OpenSSL to be compiled with PHP or the access to the openssl binary through a exec()-call.
To deal with temporary files the SetaPDF-Signer API also needs write and read access to a directory for temporary files.